This module contains integrated healthchecks for Nest. These healthchecks run in an internal execution manager based on the Terminus-package. Adds graceful shutdown and Kubernetes readiness / liveness checks for any HTTP applications. Install via npm: $ npm i @godaddy/terminus -save.
Normal Function
The NPM1 gene provides instructions for making a protein called nucleophosmin, which is found in a small region inside the nucleus of the cell called the nucleolus. Nucleophosmin shuttles back and forth between the nucleus and the fluid surrounding it (the cytoplasm). It is thought to play a part in many cellular functions, including processes involved in protein formation, DNA replication, and the progression of the cell through the step-by-step process it takes to replicate itself (called the cell cycle). In the nucleolus, nucleophosmin attaches to another protein called ARF, keeping it in the proper location and protecting it from being broken down. The ARF protein is considered a tumor suppressor because it is involved in pathways that prevent cells from growing and dividing in an uncontrolled way.
Health Conditions Related to Genetic Changes
NPM1 / NPM / Nucleophosmin Antibody (C-Terminus, DY550) LS-C141749 LifeSpan Biosciences catalog: LS-C141749. Domestic rabbit polyclonal reactivity: human. Supported plugins can be installed from the NPM repository; Installing Terminus on Ubuntu 20.10. To install Terminus on Ubuntu, the first thing you need is “gdebi”. It is an app that lets you install local “deb” packages and their dependencies effectively. Install “gdebi” using the command given below.
Acute promyelocytic leukemia
MedlinePlus Genetics provides information about Acute promyelocytic leukemia
More About This Health ConditionCytogenetically normal acute myeloid leukemia
Mutations in the NPM1 gene are involved in a form of blood cell cancer known as cytogenetically normal acute myeloid leukemia (CN-AML). While large chromosomal abnormalities can be involved in the development of acute myeloid leukemia, about half of cases do not have these abnormalities; these are classified as CN-AML. Approximately 64 percent of people with CN-AML have a mutation in the NPM1 gene.
The NPM1 gene mutations involved in CN-AML are called somatic mutations; they are found only in cells that become cancerous and are not inherited. These mutations occur in a region of the gene designated exon 12. They change the blueprint used to make the nucleophosmin protein, leading to production of a protein with an altered sequence of protein building blocks (amino acids). The alterations change the amino acid tryptophan at protein position 290 and often the tryptophan at position 288. These two tryptophans are important for localization of the protein in the nucleolus. The new sequence also provides a signal (called the nuclear export signal) for the protein to be moved out of the nucleus. As a result, the nucleophosmin protein is found in the cytoplasm rather than the nucleolus.
It is not clear how abnormal localization of the nucleophosmin protein leads to acute myeloid leukemia. Research suggests that it affects the function of the ARF protein. Because of its interaction with the altered nucleophosmin, the ARF protein is also found in the cytoplasm in cells with these genetic changes. In addition, the altered nucleophosmin protein is unable to protect ARF from being broken down. A reduction of the tumor suppressor function of the ARF protein is believed to lead to the uncontrolled production of abnormal white blood cells that occurs in acute myeloid leukemia. Other effects of NPM1 gene mutations may also be involved in the development of leukemia.
I'm exploring Dbeaver as a DB client. I have a Postgres DB stored natively that I wish to connect to, using Dbeaver (the DB is a bunch of text files containing the various tables, a ToC file explaining the various relationships, and a SQL script for rebuilding the DB on a DB client). Cannot connect to local postgresql DB using DBeaver. Dbeaver postgresql local client. In the Databases menu, click New Connection. In the Create new connection wizard that results, select the driver. On the next page of the wizard, click the driver properties tab. Enter values for authentication credentials and other properties required to connect to PostgreSQL. Cannot connect to local postgresql DB using DBeaver. Ask Question Asked 1 year, 2 months ago. Active 2 months ago. Viewed 5k times 2. I'm trying to connect to a postgresql database which is in localhost:5432 but I keep getting the error: FATAL: Ident authentication failed for user '. I installed Postgres11 on virtual machine running Centos7. DBeaver is certainly an ultimate Universal client which incorporates RDBMS and NoSQL Databases. The GUI is very useful and easy to manipulate all kind of DB queries.DBeaver is remarkably fast and stable. It loads quickly and responds instantaneously. Especially, It is the only client tool for Apache Cassandra NoSQL Database in market.
More About This Health ConditionOther cancers
A genetic rearrangement (translocation) involving the NPM1 gene is found in another blood cell cancer known as anaplastic large cell lymphoma (ALCL). Sql pro studio 2020 free. In ALCL, white blood cells known as T cells grow and divide uncontrollably and often form tumors in the lymph nodes. The translocation involved in this cancer, known as t(2;5), fuses part of the NPM1 gene on chromosome 5 with part of another gene called ALK on chromosome 2. This rearrangement is a somatic mutation.
The protein produced from the fusion gene is called NPM-ALK. Like the normal activated ALK protein, NPM-ALK turns on signaling pathways that stimulate cell growth and division (proliferation) and maturation (differentiation). Unlike ALK, the NPM-ALK protein is active all the time, which causes uncontrolled cell proliferation and leads to ALCL.
Other Names for This Gene
- B23
- NPM
- NPM_HUMAN
- nucleolar protein NO38
- nucleophosmin
- nucleophosmin (nucleolar phosphoprotein B23, numatrin)
- nucleophosmin/nucleoplasmin family, member 1
Additional Information & Resources
Terminus Mld
Tests Listed in the Genetic Testing Registry
- Tests of NPM1
Catalog of Genes and Diseases from OMIM
References
- Colombo E, Martinelli P, Zamponi R, Shing DC, Bonetti P, Luzi L, Volorio S,Bernard L, Pruneri G, Alcalay M, Pelicci PG. Delocalization and destabilizationof the Arf tumor suppressor by the leukemia-associated NPM mutant. Cancer Res.2006 Mar 15;66(6):3044-50. Citation on PubMed
- Falini B, Bolli N, Shan J, Martelli MP, Liso A, Pucciarini A, Bigerna B,Pasqualucci L, Mannucci R, Rosati R, Gorello P, Diverio D, Roti G, Tiacci E,Cazzaniga G, Biondi A, Schnittger S, Haferlach T, Hiddemann W, Martelli MF, Gu W,Mecucci C, Nicoletti I. Both carboxy-terminus NES motif and mutated tryptophan(s)are crucial for aberrant nuclear export of nucleophosmin leukemic mutants inNPMc+ AML. Blood. 2006 Jun 1;107(11):4514-23. Epub 2006 Feb 2. Citation on PubMed
- Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La StarzaR, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A,Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F,Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party. Cytoplasmicnucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl JMed. 2005 Jan 20;352(3):254-66. Erratum in: N Engl J Med. 2005 Feb 17;352(7):740. Citation on PubMed
- Falini B, Nicoletti I, Bolli N, Martelli MP, Liso A, Gorello P, Mandelli F,Mecucci C, Martelli MF. Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Haematologica. 2007 Apr;92(4):519-32.Review. Citation on PubMed
- Li J, Sejas DP, Rani R, Koretsky T, Bagby GC, Pang Q. Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitorcells. J Biol Chem. 2006 Jun 16;281(24):16536-45. Epub 2006 Apr 11. Citation on PubMed
Developer(s) | TerminusDB |
---|---|
Initial release | 2019; 2 years ago |
Stable release | |
Repository | |
Written in | Rust, Prolog[2] |
Type | Graph database |
License | |
Website | terminusdb.com |
TerminusDB is an open-sourcegraph database. It is designed for collaboratively building and curating knowledge graphs. It is a nativerevision control database that is architecturally similar to Git and other distributed version control systems. TerminusDB's is also a document store and a RDF store (as listed on DB-Engines[3]).
Data collaboration is facilitated through TerminusHub, which is a freemiumSaaS that allows users to manage access to databases and collaboratively work on shared resources.
TerminusDB is available under the permissiveApache 2.0 license.[4] The development team claim that it will be 'open source now and forever'.[5] TerminusDB is implemented in Prolog and Rust and accessible using a transactional HTTP endpoint. TerminusDB uses JSON-LD as a lightweight, language-independent data interchange format.
History[edit]
DataChemist[edit]
TerminusDB, previously known as DataChemist,[6][7][8] was founded in Dublin, Ireland. It was launched by Irish TánaisteSimon Coveney in August 2018.[9] TerminusDB opened a research and development hub in Utrecht, Netherlands in 2019.[10]
ALIGNED Project[edit]
Starting in Trinity College Dublin,[11] the development team behind TerminusDB ran the Horizon 2020 project ALIGNED that worked from February 2015 to January 2018.[12][13][14] An open-accesse-book entitled Engineering Agile Big-Data Systems was published on completion of the ALIGNED project[15]
Seshat[edit]
Seshat is an international scientific research project of the nonprofitEvolution Institute which uses TerminusDB as data infrastructure.[16] Seshat has been working with the development team from the ALIGNED project onward.[17] This work has been reported in several major newspapers.[18][19] TerminusDB is also the database behind the associated Institute for Economics and Peace and Oxford Universityhistorical peace index project.[20]
The results of some aspects of this research, focused on the relationship between complex societies and moralizing gods, appeared in Nature,[21] the prestigious scientific journal. Kevin Feeney, one of the founders of TerminusDB, is an author of the paper and sits on the Board of directors of Seshat.[22]
Open source[edit]
Version 1.0 was released in October 2019.[23] TerminusDB was first released under the GPLv3 licence with the client libraries are released with the Apache 2 licence. TerminusDB 1.1, with the newly integrated terminus-store, was released in January 2020.[24] Version 2.0 of the database was released in June 2020[25] and 3.0 was released in July 2020.[26] Version 4.0 was released in December 2020[27] under the Apache 2.0 license. The shift was discussed extensively.[28]
Name[edit]
TerminusDB is named after the Roman God of Boundaries, Terminus. It is also named after the home planet of the Foundation in the series of science-fiction novel by Issac Asimov.[29] TerminusDB uses a CowDuck mascot - the motif finds its origins in the examples used by core engineer Matthijs van Otterdijk when first demonstrating the append only immutable data store[30]
Main features[edit]
TerminusDB is a full featured in-memory graph database management system with a rich query language. The design of the underlying data structure, which is implemented in a Rust library, uses a succinct data structures and delta encoding approach drawing inspiration from software source control systems like Git.[31] This allows all of the Git semantics to be used in TerminusDB.
The TerminusDB infrastructure is based on the RDF standard. This standard specifies finite labelled directed graphs which are parameteric in some universe of datatypes. The names for nodes and labels are drawn from a set of IRIs (Internationalized Resource Identifiers). TerminusDB uses the XSD datatypes as its universe of concrete values. For schema design, TerminusDB uses the OWL language with two modifications to make it suitable as a schema language; it dispenses with the open world interpretation and insist on the unique name assumption.[32] This provides a rich modelling language which enables constraints on the allowable shapes in the graph. TerminusDB supports a subset of OWL that provides for the following schematic control features:
With Deezer Premium, you don't need to be connected to the internet to enjoy your favorite tracks. Just download them once and listen offline whenever you want. So whether you're saving your data or going into the wild, you never have to leave your music behind. Check out Deezer Premium. Deezer Premium Apk offers many channels for you to choose from, based on music genres loved by users all over the world such as Indie, Pop, Hip-Hop, EDM, Rock, Blues and more. Deezer Premium Apk allows users to download and save favorite songs and listen to them offline when there is no internet connection. This feature is available for Premium accounts only. With Deezer Premium, you get one account, and you can connect up to 3 different devices. Deezer Family lets you create up to 6 different members on one account, so that everyone can create their own collection and have their own personal recommendations. You can also connect up to 13 different devices, and listen simultaneously. Deezer premium app store.
- Classes and sub-classes for modelling taxonomies and inheritance hierarchies, with special classes for modelling complex relationships and entities
- Typed properties for modelling the attributes of things
- Datatypes for modelling the different types of data
- Scopings for modelling things that change with time, space and confidence
- Constraints for applying logic and rules to things[33]
TerminusDB has a promise based client for the browser and node.js it is available through the npm registry, or can be directly included in web-sites.[34] It also has a Python client for the TerminusDB RESTfulAPI and the pythonic version of the web object query language, WOQLpy.[35]
Query language[edit]
WOQL (web object query language) is a datalog-based query language. It allows TerminusDB to treat the database as a document store or a graph interchangeably, and provides query features to make relationship traversals easy. WOQL's primary syntax and interchange format is in JSON-LD. This gives a relatively straightforward human-readable format which can be easily stored in TerminusDB itself.
Example[edit]
This demonstrates a simple query which creates a document in the database, along with labels and cardinality constraints.[36]
See also[edit]
Terminus Mac
References[edit]
- ^'RELEASE_NOTES'.
- ^'TerminusDB Repository'.
- ^'TerminusDB System Properties'. db-engines.com. Retrieved 2020-12-09.
- ^'We Love GPLv3, but are Switching License to Apache 2.0: TerminusDB'. Graph Database Blog - News and Tutorials from TerminusDB. Retrieved 2020-12-09.
- ^Feeney, Luke (2019-10-07). 'Today we release TerminusDB — the database for data people'. Medium. Retrieved 2020-12-09.
- ^'DataChemist wants to make sense of big-picture intelligence in the data analytics 'arms race''. Fora.ie. Retrieved 2020-05-06.
- ^'Startup Scout: Companies to watch in 2020'. Fora.ie. Retrieved 2020-05-06.
- ^'Innovadores | Cómo lograr la paz en el mundo con ayuda del big data'. Innovadores (in Spanish). Retrieved 2020-05-06.
- ^'If data is the new oil, DataChemist is the refinery'. 2018-08-27.Cite journal requires
|journal=
(help) - ^Earley, Kelly (2019-11-20). 'Dublin's DataChemist announces expansion into the Netherlands'. Silicon Republic. Retrieved 2020-05-06.
- ^'Show HN: TerminusDB – An open source in-memory graph database | Hacker News'. news.ycombinator.com. Retrieved 2020-05-06.
- ^'CORDIS EU Research Results'.
- ^'Project ID: 644055; Aligned, Quality-centric Software and Data Engineering'.
- ^'ALIGNED Project Website'.
- ^Feeney, Kevin; Davies, Jim; Welch, James; Hellmann, Sebastian; Dirschl, Christian; Koller, Andreas; Francois, Pieter; Marciniak, Arkadiusz (2018-10-30). Engineering Agile Big-Data Systems. River Publishers. ISBN978-87-7022-016-3.
- ^'Who We Are'. Seshat: Global History Databank. Retrieved 2020-05-06.
- ^Kevin, Feeney; Jim, Davies; Sebastian, Hellmann (2018-11-05). Engineering Agile Big-Data Systems. River Publishers. ISBN978-87-7022-016-3.
- ^Thursday; December 21; Am, 2017-11:20 (2017-12-21). 'Trinity data behind new research which suggests common path governed evolution of societies'. www.irishexaminer.com. Retrieved 2019-12-06.CS1 maint: numeric names: authors list (link)
- ^Ahlstrom, Dick. 'Trinity big data researchers to lead €4m quality control effort'. The Irish Times. Retrieved 2019-12-06.
- ^Gleeson, Colin. 'Dublin start-up chosen to work on global peace initiative'. The Irish Times. Retrieved 2019-12-06.
- ^Whitehouse, Harvey; François, Pieter; Savage, Patrick E.; Currie, Thomas E.; Feeney, Kevin C.; Cioni, Enrico; Purcell, Rosalind; Ross, Robert M.; Larson, Jennifer; Baines, John; ter Haar, Barend (2019-03-20). 'Complex societies precede moralizing gods throughout world history'. Nature. 568 (7751): 226–229. Bibcode:2019Natur.568.226W. doi:10.1038/s41586-019-1043-4. hdl:10871/36936. ISSN0028-0836. PMID30894750. S2CID84186554.
- ^'Who We Are'. Retrieved 2020-07-22.
- ^Feeney, Luke (2019-10-07). 'Today we release TerminusDB — the database for data people'. Medium. Retrieved 2019-12-06.
- ^Feeney, Luke (2020-01-28). 'TerminusDB 1.1 — The Big Babushka'. Medium. Retrieved 2020-05-06.
- ^'TerminusDB 2.0 Alpha Release'. TerminusDB. 2020-06-04. Retrieved 2020-07-22.
- ^'RELEASE NOTES'. 2020-11-22.
- ^'terminusdb/terminusdb'. GitHub. Retrieved 2020-12-09.
- ^'We Love GPLv3, but Are Switching License to Apache 2.0 | Hacker News'. news.ycombinator.com. Retrieved 2020-12-09.
- ^Feeney, Luke (2019-10-01). 'TerminusDB — what's in a name?'. Medium. Retrieved 2019-12-06.
- ^terminusdb/terminus-store, TerminusDB, 2020-05-06, retrieved 2020-05-06
- ^'Succinct Data Structures and Delta Encoding for Modern Databases'(PDF).
- ^Brennan, Rob (2018). 'Linked data schemata: fixing unsound foundations'. Semantic Web. 9 (1): 53–75 – via DORAS.
- ^'TerminusDB Documentation - the database for data people'. terminusdb.com. Retrieved 2020-05-06.
- ^terminusdb/terminus-client, TerminusDB, 2020-04-29, retrieved 2020-05-06
- ^terminusdb/terminus-client-python, TerminusDB, 2020-05-06, retrieved 2020-05-06
- ^'Taking TerminusDB to The Bank (Part I)'. Graph Database Blog - News and Tutorials from TerminusDB. Retrieved 2020-12-09.
External links[edit]
- Official website
Retrieved from 'https://en.wikipedia.org/w/index.php?title=TerminusDB&oldid=1017666692'